Toplumdan kazanılmış zatüre (pnömoni) sık gördüğüm bir hastalıktır. ABD’de yılda her 1000 insana karşı 12 atak görülmektedir. Bu zatüre ataklarına bazen kanser neden olabilmektedir. Bu tip durumlarda (postobstrüktif pnömoni), zatüre tedavi edildikten sonra çekilen akciğer filmlerinde, daha önce zatüre alanı nedeniyle görülemeyen, kansere ait kitle görünebilmektedir. Okumaya devam et
Tag Archives: Lung Cancer
Akciğer kanseri aslında kendi yarattığımız bir canavar; daha önce de bahsetmiştim, ama tekrar hatırlatayım; 1900 öncesi yazılan tıp kitaplarında akcieğr kanseri nadir bir hastalıktır, dolayısıyla klinik önemi bilinmemektedir ibaresi yer alırken, günümüzde kanserden ölümlerin bir numaralı sebebidir. Bu durumun da en büyük sebebi sigara (ve diğer tütün ürünleridir). Okumaya devam et
Impact of Environmental Tobacco Smoke on the Incidence of Mutations in Epidermal Growth Factor Receptor Gene in Never-Smoker Patients With Non–Small-Cell Lung Cancer
The heading is long, but the fact is short and brief: if someone around you smokes, you are a smoker, too. The never smoker non-small-cell lung cancer (NSCLC) patients have high percentage of EGFR mutations in their tumor cells than smokers, and these mutations make the neoplastic cells(cancer cells) prone to anti-neoplastic effects of Tyrosine Kinase Inhibitors (TKI) such as erlotinib, or gefitinib. Nevertheless, the smokers’ cancer cells mostly do not have these mutations, so no clear benefit from TKI’s is generally achieved.
Dr. Young Joo Lee, and his colleagues has shown that environmental tobacco smoke exposure is negatively associated with EGFR mutations in never smokers with NSCLC.
So the motto of smokers should not be: “Live (smoke) and let die!”
Journal of Clinical Oncology, Vol 28, No 3 (January 20), 2010: pp. 487-492
The casual relationship with smoking and lung cancer is a well established fact. However, it was not well-known whether quitting smoking after a diagnosis of early stage lung cancer is of beneficial. A Parson and his colleagues found a correlation between smoking and prognosis in aforementioned patients. The patients who continued smoking after the diagnosis did worse than their counterparts. In this meta-analysis published in British Medical Journal, the authors concluded that:”the estimated number of deaths prevented is larger than would be expected from reduction of cardiorespiratory deaths after smoking cessation, so most of the mortality gain is likely to be due to reduced cancer progression. These findings indicate that offering smoking cessation treatment to patients presenting with early stage lung cancer may be beneficial. “
In a recent study that was published in Journal of Clinical Oncology, Elizabeth A. Chrischilles, and her colleagues showed that elder people with advanced non small cell lung cancer (advanced means that the disease cannot be usually treated with surgery) are treated less often with chemotherapy in respect to the younger ones, however they face more adverse events during chemotherapy. The authors concluded that: ” Potential implicit trade-offs between symptom management and treatment toxicity should be made explicit and additionally studied. “
Journal of Clinical Oncology, Vol 28, No 4 (February 1), 2010: pp. 620-627